Abstract: Clinical Analysis of 8 Patients with Primary Angiosarcoma of the BreastXue GUO1, Zhonglan YU2, Lijuan WEI1, Lei ZHENG1, Juntian LIU1Correspondence to: LIU Juntian, e-mail:ljt641024@yahoo.cn1Department Ⅱof Breast Cancer, Cancer Institute and Hospital of Tianjin Medical University, Tianjin 300060, China2Cangxian Hospital, Cangzhou 061000, Hebei, ChinaAbstract Objective: To investigate the clinicopathologic charateristics, diagnosis, treatment, and prognosis of primaryangiosarcoma of the breast (PAB). Methods: The clinicopathologic data of 8 PAB patients treated in our hospital betweenDecember 1975 and August 2009 were retrospectively analyzed. Results: Of the 8 patients in the study one was male. Themedian age was 44.5 years (ranged 20-60). All patients were admitted to our hospital with breast masses as the first clini-cal symptom. The median diameter of the tumors was 6.0 cm (2.5 ～ 8 cm). The skin over the surface of the tumor dis-played color changes of different degrees. Surgery was the preferred treatment. Postoperative pathologic results showedthat poorly or moderately differentiated angiosarcoma was seen in one case, angiosarcoma of moderate differentiation wasseen in 4 cases, and well-differentiated tumor was seen in 3 cases. No obvious lymph-node metastasis was found. Postop-erative adjuvant chemotherapy was conducted in 4 cases, and radiotherapy and hyperthermia were administered in one ofthe 8 cases. Local recurrence occurred in 4 cases after surgery, and the median time to the first recurrence was 31 months(12～48 months). Distant metastases occurred in 3 of the 8 cases, with the sites of metastasis including lung, bone, liver,ovary, head and skin. The median time to metastasis was 84 months (54～291). A postoperative follow-up with mediantime of 54 months (7 ～300 months) showed 4 cases had died, 2 cases had disease-free survival, and 2 cases were lost tofollow up. Conclusion: Primary angiosarcoma of the breast is a rare malignant tumor with poor clinical prognosis. The skinover the surface of the tumor displays color changes, and the clinical manifestations are often confused with those of be-nign tumors. Recurrence and metastasis after surgery frequently occurred. Hematogenous metastasis is more commonthan lymphatic metastasis. Currently the major treatment for PAB is surgery with mastectomy. Patient survival is not in-creased after treatment with adjuvant chemotherapy and radiotherapy.Keywords Angiosarcoma of the breast; Therapy; Recurrence; Prognosis